Scientific Reports A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models Click Here International Journal of Molecular Sciences Allosteric Modulation of GCase Enhances Lysosomal Activity and Reduces ER Stress in GCase-Related Disorders Click Here Journal of Medicinal Chemistry Use of the Novel Site-Directed Enzyme Enhancement Therapy (SEE-Tx) Drug Discovery Platform to Identify Pharmacological Chaperones for Glutaric Acidemia 1 Click Here INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Developing Allosteric Chaperones for GBA1-Associated Disorders—An Integrated Computational and Experimental Approach Click Here PLOS One Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type 1 Click Here PLOS One Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors-min Click Here Nature Scientific Reports Tau accumulation in degradative organelles is associated to lysosomal stress Click Here Current Drug Discovery Technologies Extracting Atomic Contributions to Binding Free Energy Using Molecular Dynamics Simulations with Mixed Solvents (MDmix) Click Here
