About Us

Offer Description:

We are seeking a biophysicist or structural biologist (PhD, preferably with postdoctoral experience) to plan, manage and support all tasks related to protein production, biophysical assays, and structural biology. As a core member of the discovery team, the selected candidate will be able to work effectively in a multidisciplinary team and will have a good understanding of the drug discovery process.

Main Tasks and Responsibilities:

• Proposing the most appropriate activities/assays to support our internal drug discovery projects at each stage of development, from target evaluation to drug candidate selection.

• Identifying the optimal partner (specialized CROs or selected academic partners) and/or developing the internal capacities to perform each activity.

• Supervising the activities, to ensure that they are completed on time and according to the best standards.

• Set-up and executing experiments in house.

• Troubleshooting and finding alternatives, as needed.

• Identification and evaluation of new technologies.

• Facilitating productive collaborations with colleagues in computational chemistry, medicinal chemistry, biology and drug development.

• Communicating the results internally, ensuring their impact on the projects.

Essential Requirements:

• Doctoral degree in biophysics or structural biology.

• Experience in several of the following techniques and a good working knowledge of the rest:

  • Protein production and purification

  • NMR

  • X-ray crystallography

  • Protein mass spectrometry

  • SPR

  • Microcalorimetry

  • Fluorescence-based assays.

• Fluent in English.

• High flexibility. Can cope with change.

• Responds well to scientific challenge and applies significant rigor to their own work.

Additional Skills:

• Post-doctoral experience .

• Good written and oral communication skills; enthusiasm, self-motivation, strong interpersonal skills, ability to interact within a multidisciplinary team.

• Comfortable working a highly innovative team environment.

We Offer:

• Full time contract. Salary will be commensurate with academic level and experience.

• Stimulating, interdisciplinary research and high-quality international scientific environment.

• Measures to reconcile work and family life.

• Eligible for Employee Referral Bonus.

How to apply:

Interested applicants should send their CV, cover letter and contact of two references to: This email address is being protected from spambots. You need JavaScript enabled to view it. and mention for which position they apply.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Offer Description:

We are looking for a junior cell biologist who will join the Biology Team at Gain Therapeutics. The candidate will bring his/her biological expertise and understand goals of the project to contribute to the development of treatments of diseases associated with protein misfolding such as rare genetic and neurodegenerative diseases. 

Main Tasks and Responsibilities:

• Conduct experiments and write reports summarizing findings and conclusions.

• Build effective partnerships with other teams at Gain Therapeutics.

• Contribute to the management of externalized work.

• Provide scientific guidance and support to the other members of the Biology Team. Solve everyday problems in the laboratory.

• Contribute to laboratory maintenance as part of the team.

• Maintain an up-to-date knowledge of the relevant scientific literature.

Essential Requirements:

• Doctoral degree in disciplines such as Biology, Pharmacy or Biochemistry or related field.

• Proven laboratory experience with excellent attention to detail. Experience in cell culture is a must.

• Strong organizational skills.

• Ability to manage multiple projects simultaneously to deliver against deadlines.

• High flexibility. Can cope with change.

• Responds well to scientific challenge and applies significant rigor to their own work.

• Fluent in English.

Additional Skills:

• Experience in biophysics and biochemical assays.

We Offer:

• Full time contract. Salary will be commensurate with academic level and experience.

• Stimulating, interdisciplinary research and high-quality international scientific environment.

• Measures to reconcile work and family life.

• Eligible for Employee Referral Bonus.

The above statements reflect the usual responsibilities and principal functions of the position and shall not be construed as a complete description of all the work requirements that may be inherent or added to the position.

To apply:

Interested applicants should send their CV, cover letter and contact of two references to: This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Offer Description:

We are seeking a computational chemist with solid background on molecular simulations eager to pursue/consolidate a career in structure-based drug discovery. The work involves target assessment (druggability analysis), hit identification (virtual screening), stablishing structure-activity relationships and supporting a multidisciplinary team in the identification of clinical candidates.

Essential Requirements:

The ideal candidate holds a PhD, optionally with 2-3 years of post-doc experience, has a solid theoretical understanding of molecular recognition (protein-ligand association, protein folding), demonstrated experience in the use of molecular dynamics and is skilled in programming/scripting tools that ensure reproducibility and efficiency. Advanced analytical and critical problem-solving skills are essential.

The ability to deal with multiple tasks and deliver results in a timely manner is essential. Equally important, the selected candidate will be able to work effectively in a multidisciplinary team, will be proactive in the identification of tasks to support the project and will communicate the results in a clear and effective manner.

The following specific computational chemistry skills are considered essential. The candidate should be proficient on most of them, and will be able to master the rest in a short amount of time.

• Molecular dynamics

• Molecular docking (protein-ligand)

• MD-based free energy calculations

• Advanced method for analysis of MD trajectories (e.g. MSM, clustering)

• Experience in the use of X-ray crystallographic or cryo-EM data

• As someone familiar in the use of computers, the candidate will have excellent command of shell scripting, python programming and the use of high-performance computing environments.

Essential Requirements:

Knowledge on one or more of these specific areas is an important advantage:

• Chemoinformatics

• Machine learning

• Homology modelling

• Bioinformatics

Knowledge of adjacent scientific areas, such as structural biology, medicinal chemistry, molecular biology, pharmacology, etcetera, will facilitate the integration in multidisciplinary teams and will be considered as a plus.

We Offer:

• Full time contract. Salary will be commensurate with academic level and experience.

• Stimulating, interdisciplinary research and high-quality international scientific environment.

• Measures to reconcile work and family life.

• Eligible for Employee Referral Bonus.

To apply:

Interested candidates should send a letter of motivation, CV and two contacts that can provide references to This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it.